Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM04749)
  Official Symbol
ARMC1
  Official Full Name
armadillo repeat containing 1
  Synonym
Arcp;FLJ10511
  Molecule Type
Protein coding
  Position On Chromosome
chr8(Start:65602458 - End:65634217)
  Strand
-
  Uniprot Entry
Q9NVT9 
  ENSG ID
ENSG00000104442 
  Dnmivd Disease
HNSC 
    Disease Relevance (Click to Show/Hide)
         1F84: Opisthorchiasis Opisthorchis viverrini [Opisthorchiasis]
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         2A00: Primary neoplasms of brain Glioma [Primary neoplasms of brain]
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         2A01: Primary neoplasms of meninges Meningioma [Primary neoplasms of meninges]
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         2A90: Mature T-cell lymphoma, specified types, nodal or systemic Anaplastic large cell lymphoma (ALCL) [Mature T-cell lymphoma, specified types, nodal or systemic]
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         2B6B: Malignant neoplasms of nasopharynx Nasopharyngeal carcinoma (NPC) [Malignant neoplasms of nasopharynx]
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         2B70: Malignant neoplasms of oesophagus Barrett's esophagus and esophageal adenocarcinoma [Malignant neoplasms of oesophagus]
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         2B70: Malignant neoplasms of oesophagus Esophageal adenocarcinoma (EAC) [Malignant neoplasms of oesophagus]
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         2B72: Malignant neoplasms of stomach Gastric cancer [Malignant neoplasms of stomach]
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         2B90: Malignant neoplasms of colon Colon adenocarcinoma [Malignant neoplasms of colon]
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         2B90: Malignant neoplasms of colon Colorectal cancer [Malignant neoplasms of colon]
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         2C10: Malignant neoplasm of pancreas Pancreatic ductal adenocarcinoma (PDAC) [Malignant neoplasm of pancreas]
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         2C12: Malignant neoplasms of liver or intrahepatic bile ducts Liver cancer [Malignant neoplasms of liver or intrahepatic bile ducts]
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         2C25: Malignant neoplasms of bronchus or lung Lung adenocarcinoma [Malignant neoplasms of bronchus or lung]
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         2C25: Malignant neoplasms of bronchus or lung Lung cancer [Malignant neoplasms of bronchus or lung]
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         2C25: Malignant neoplasms of bronchus or lung Non small cell lung cancer (NSCLC) [Malignant neoplasms of bronchus or lung]
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         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
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         2C60: Carcinoma of breast Breast cancer [Carcinoma of breast]
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         2D10: Malignant neoplasms of thyroid gland Thyroid tumors [Malignant neoplasms of thyroid gland]
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         4A40: Lupus erythematosus Systemic lupus erythematosus (SLE) [Lupus erythematosus]
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         5B81: Obesity Obesity [Obesity]
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         6A02: Autism spectrum disorder Autism [Autism spectrum disorder]
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         6A20: Schizophrenia Schizophrenia [Schizophrenia]
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         6E8Z: Mental, behavioural or neurodevelopmental disorders Psychiatric disorders [Mental, behavioural or neurodevelopmental disorders]
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         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
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         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
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         9A01: Infectious disorders of eyelid Human eye and its diseases [Infectious disorders of eyelid]
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         BD40: Atherosclerotic chronic arterial occlusive disease Atherosclerosis [Atherosclerotic chronic arterial occlusive disease]
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         CA22: Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease (COPD) [Chronic obstructive pulmonary disease]
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         FA20: Rheumatoid arthritis Rheumatoid arthritis [Rheumatoid arthritis]
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         GA10: Endometriosis Endometriosis [Endometriosis]
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         JA24: Pre-eclampsia Preeclampsia (PE) [Pre-eclampsia]
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         LA02: Spina bifida Neural tube defects (NTDs) [Spina bifida]
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         LA4Z: Clefts of lip, alveolus or palate Non-syndromic cleft lip and palate [Clefts of lip, alveolus or palate]
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         MG30: Chronic pain Fibromyalgia [Chronic pain]
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         SD86: Dementia disorder Dementia [Dementia disorder]
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         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
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         XB8M: Congenital Melanoma [Congenital]
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         XH0945: Squamous cell carcinoma Head and neck squamous cell cancer (HNSCC) [Squamous cell carcinoma]
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         XH1E13: Germinoma Germinoma [Germinoma]
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         XH1XF3: Osteosarcoma Osteosarcoma [Osteosarcoma]
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         XH3DV3: Adenoma Adenoma [Adenoma]
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         XH4546: Signet ring cell carcinoma Signet ring cell colorectal cancer [Signet ring cell carcinoma]
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         XH46F1: Clear cell renal cell carcinoma Clear cell renal cell carcinoma (ccRCC) [Clear cell renal cell carcinoma]
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         XH4KH2: Adrenal cortical carcinoma Adrenal cortical cancer [Adrenal cortical carcinoma]
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         XH4S92: Leukaemia Leukemia [Leukaemia]
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         XH4V32: Ductal carcinoma in situ Ductal carcinoma in situ (DCIS) [Ductal carcinoma in situ]
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         XH4W48: Hepatocellular carcinoma Hepatocellular carcinoma (HCC) [Hepatocellular carcinoma]
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         XH6PH6: Astrocytoma Astrocytoma [Astrocytoma]
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         XH7F82: Glioblastoma Glioblastoma [Glioblastoma]
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         XH7PW5: Lymphocytic leukaemia Pediatric acute lymphoblastic leukemia [Lymphocytic leukaemia]
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         XH7ZQ4: Atypical teratoid/rhabdoid tumour Atypical teratoid/rhabdoid tumor (ATRT) [Atypical teratoid/rhabdoid tumour]
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         XH85Z0: Neuroblastoma Neuroblastoma [Neuroblastoma]
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         XH8844: Oligodendroglioma, anaplastic Anaplastic oligodendrogliomas/oligoastrocytomas [Oligodendroglioma, anaplastic]
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         XH8AA5: Acute myeloid leukaemia Acute myeloid leukemia (AML) [Acute myeloid leukaemia]
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         XH8P29: Medulloblastoma Medulloblastoma [Medulloblastoma]
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         XH8P29: Medulloblastoma Primary medulloblastoma [Medulloblastoma]
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         XH8SH6: CNS embryonal tumour Primitive neuroectodermal tumors [CNS embryonal tumour]
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         XH9HQ1: Gastrointestinal stromal tumour Gastrointestinal stromal tumors (GIST) [Gastrointestinal stromal tumour]
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         XN487: Human immunodeficiency virus Human immunodeficiency virus (HIV) [Human immunodeficiency virus]
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Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate ARMC1 CpG site in breast cancer cells.

Protein(s) with this epigenetic modification
  Protein Name: Rv2966c
     Detailed Information Pro Info click to show the detail information of this protein [3]
     Description
Rv2966c could hypermethylate the non-CpG dinucleotides at the host ARMC1 (geneBody) genetic loci during Mycobacterium tuberculosis H37Rv infection.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
3 Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection. Sci Rep. 2016 Apr 26;6:25006. doi: 10.1038/srep25006.

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