Details of Epigenetic Molecule(EM)
General Information of EM (ID: EM03002) | |||||||
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Official Symbol |
MTREX
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Official Full Name |
Mtr4 exosome RNA helicase
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Synonym |
Dob1;KIAA0052;Mtr4;SKIV2L2;fSAP118
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Molecule Type |
Protein coding
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Position On Chromosome |
chr5(Start:55307989 - End:55425579)
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Strand |
+
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Uniprot Entry | |||||||
ENSG ID | |||||||
Dnmivd Disease | |||||||
Disease Relevance (Click to Show/Hide) | |||||||
2A00: Primary neoplasms of brain | Glioma [Primary neoplasms of brain] | ||||||
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2A01: Primary neoplasms of meninges | Meningioma [Primary neoplasms of meninges] | ||||||
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2B70: Malignant neoplasms of oesophagus | Esophageal adenocarcinoma (EAC) [Malignant neoplasms of oesophagus] | ||||||
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2B90: Malignant neoplasms of colon | Colon adenocarcinoma [Malignant neoplasms of colon] | ||||||
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2B90: Malignant neoplasms of colon | Colorectal cancer [Malignant neoplasms of colon] | ||||||
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2C60: Carcinoma of breast | Breast cancer [Carcinoma of breast] | ||||||
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4A40: Lupus erythematosus | Systemic lupus erythematosus (SLE) [Lupus erythematosus] | ||||||
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5B81: Obesity | Obesity [Obesity] | ||||||
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6A00: Disorders of intellectual development | Intellectual disability and congenital anomalies(ID/CA) [Disorders of intellectual development] | ||||||
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8A20: Alzheimer disease | Alzheimer's disease [Alzheimer disease] | ||||||
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8A40: Multiple sclerosis | Multiple sclerosis [Multiple sclerosis] | ||||||
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9A01: Infectious disorders of eyelid | Human eye and its diseases [Infectious disorders of eyelid] | ||||||
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BD40: Atherosclerotic chronic arterial occlusive disease | Atherosclerosis [Atherosclerotic chronic arterial occlusive disease] | ||||||
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DD70: Crohn disease | Crohn's disease [Crohn disease] | ||||||
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FA21: Psoriatic arthritis | Psoriatic [Psoriatic arthritis] | ||||||
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GA10: Endometriosis | Endometriosis [Endometriosis] | ||||||
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LA02: Spina bifida | Neural tube defects (NTDs) [Spina bifida] | ||||||
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SD86: Dementia disorder | Dementia [Dementia disorder] | ||||||
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XB8M: Congenital | Melanoma [Congenital] | ||||||
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XH1E13: Germinoma | Germinoma [Germinoma] | ||||||
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XH3DV3: Adenoma | Adenoma [Adenoma] | ||||||
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XH4W48: Hepatocellular carcinoma | Hepatocellular carcinoma (HCC) [Hepatocellular carcinoma] | ||||||
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XH6PH6: Astrocytoma | Astrocytoma [Astrocytoma] | ||||||
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XH7PW5: Lymphocytic leukaemia | Pediatric acute lymphoblastic leukemia [Lymphocytic leukaemia] | ||||||
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XH7ZQ4: Atypical teratoid/rhabdoid tumour | Atypical teratoid/rhabdoid tumor (ATRT) [Atypical teratoid/rhabdoid tumour] | ||||||
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XH8AA5: Acute myeloid leukaemia | Acute myeloid leukemia (AML) [Acute myeloid leukaemia] | ||||||
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XH8P29: Medulloblastoma | Primary medulloblastoma [Medulloblastoma] | ||||||
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XH8P29: Medulloblastoma | Medulloblastoma [Medulloblastoma] | ||||||
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XH9HQ1: Gastrointestinal stromal tumour | Gastrointestinal stromal tumors (GIST) [Gastrointestinal stromal tumour] | ||||||
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XN487: Human immunodeficiency virus | Human immunodeficiency virus (HIV) [Human immunodeficiency virus] | ||||||
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Metabolite(s) with this epigenetic modification | |||||||
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Metabolite Name: Valerate | |||||||
Detailed Information |
Meta Info
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[1], [2] | |||||
Description |
Valerate has been shown to hypermethylate SKIV2L2 CpG site in breast cancer cells.
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Protein(s) with this epigenetic modification | |||||||
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Protein Name: Rv2966c | |||||||
Detailed Information |
Pro Info
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[3] | |||||
Description |
Rv2966c could hypermethylate the non-CpG dinucleotides at the host SKIV2L2 (geneBody) genetic loci during Mycobacterium tuberculosis H37Rv infection.
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