Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM02269)
  Official Symbol
AGTR1
  Official Full Name
angiotensin II receptor type 1
  Synonym
AG2S;AGTR1A;AGTR1B;AT1;AT1AR;AT1B;AT1BR;AT1R;AT2R1;AT2R1A;AT2R1B;HAT1R
  Molecule Type
Protein coding
  Position On Chromosome
chr3(Start:148697784 - End:148743008)
  Strand
+
  Uniprot Entry
P30556 
  ENSG ID
ENSG00000144891 
  Dnmivd Disease
COAD 
    Disease Relevance (Click to Show/Hide)
         1B10: Tuberculosis of the respiratory system Tuberculosis (TB) [Tuberculosis of the respiratory system]
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         2A00: Primary neoplasms of brain Oligodendroglial tumors [Primary neoplasms of brain]
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         2A01: Primary neoplasms of meninges Meningioma [Primary neoplasms of meninges]
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         2B50: Chondrosarcoma Central chondrosarcoma [Chondrosarcoma]
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         2B6B: Malignant neoplasms of nasopharynx Nasopharyngeal carcinoma (NPC) [Malignant neoplasms of nasopharynx]
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         2B6E: Malignant neoplasms of other or ill-defined sites in the lip, oral cavity or pharynx Oral or pharyngeal squamous cell carcinoma (OPSCC) [Malignant neoplasms of other or ill-defined sites in the lip, oral cavity or pharynx]
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         2B72: Malignant neoplasms of stomach Gastric cancer [Malignant neoplasms of stomach]
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         2B80: Malignant neoplasms of small intestine Small intestinal neuroendocrine tumours (SINETs) [Malignant neoplasms of small intestine]
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         2B90: Malignant neoplasms of colon Colon adenocarcinoma [Malignant neoplasms of colon]
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         2C25: Malignant neoplasms of bronchus or lung Lung adenocarcinoma [Malignant neoplasms of bronchus or lung]
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         2C25: Malignant neoplasms of bronchus or lung Lung cancer [Malignant neoplasms of bronchus or lung]
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         2C25: Malignant neoplasms of bronchus or lung Non small cell lung cancer (NSCLC) [Malignant neoplasms of bronchus or lung]
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         2C31: Squamous cell carcinoma of skin Cutaneous squamous cell carcinoma [Squamous cell carcinoma of skin]
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         2C60: Carcinoma of breast Breast cancer [Carcinoma of breast]
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         2C82: Malignant neoplasms of prostate Prostate cancer [Malignant neoplasms of prostate]
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         2D10: Malignant neoplasms of thyroid gland Thyroid tumors [Malignant neoplasms of thyroid gland]
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         4A20: Acquired immunodeficiencies Immunodeficiency [Acquired immunodeficiencies]
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         4A43: Overlap or undifferentiated nonorgan specific systemic autoimmune disease Sjgren's Syndrome [Overlap or undifferentiated nonorgan specific systemic autoimmune disease]
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         4A84: Anaphylaxis Allergy [Anaphylaxis]
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         5B81: Obesity Obesity [Obesity]
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         6A02: Autism spectrum disorder Autism [Autism spectrum disorder]
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         6E8Z: Mental, behavioural or neurodevelopmental disorders Psychiatric disorders [Mental, behavioural or neurodevelopmental disorders]
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         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
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         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
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         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
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         9A01: Infectious disorders of eyelid Human eye and its diseases [Infectious disorders of eyelid]
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         BD40: Atherosclerotic chronic arterial occlusive disease Atherosclerosis [Atherosclerotic chronic arterial occlusive disease]
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         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
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         DD70: Crohn disease Crohn's disease [Crohn disease]
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         FA0Z: Osteoarthritis Osteoarthritis (OA) [Osteoarthritis]
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         FA20: Rheumatoid arthritis Rheumatoid arthritis [Rheumatoid arthritis]
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         GA10: Endometriosis Endometriosis [Endometriosis]
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         LA02: Spina bifida Neural tube defects (NTDs) [Spina bifida]
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         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
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         SD86: Dementia disorder Dementia [Dementia disorder]
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         XB1Y: Familial Familial recurrent moles (RHM) [Familial]
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         XB8M: Congenital Melanoma [Congenital]
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         XH0945: Squamous cell carcinoma Head and neck squamous cell cancer (HNSCC) [Squamous cell carcinoma]
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         XH1E13: Germinoma Germinoma [Germinoma]
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         XH4546: Signet ring cell carcinoma Signet ring cell colorectal cancer [Signet ring cell carcinoma]
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         XH4S92: Leukaemia Leukemia [Leukaemia]
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         XH7ZQ4: Atypical teratoid/rhabdoid tumour Atypical teratoid/rhabdoid tumor (ATRT) [Atypical teratoid/rhabdoid tumour]
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         XH8D74: Carcinomatosis Cancer [Carcinomatosis]
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         XH8P29: Medulloblastoma Medulloblastoma [Medulloblastoma]
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         XH8P29: Medulloblastoma Primary medulloblastoma [Medulloblastoma]
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         XN487: Human immunodeficiency virus Human immunodeficiency virus (HIV) [Human immunodeficiency virus]
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Metabolite(s) with this epigenetic modification
  Metabolite Name: Riboflavin (B2)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
RIboflavin (B2) has been shown to resulte in CpG site-specific alterations in methylation at AGTR1 loci in adults with the TT genotype.

Protein(s) with this epigenetic modification
  Protein Name: Rv2966c
     Detailed Information Pro Info click to show the detail information of this protein [3]
     Description
Rv2966c could hypermethylate the non-CpG dinucleotides at the host AGTR1 (intergenic) genetic loci during Mycobacterium tuberculosis H37Rv infection.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Biotinylation of histones represses transposable elements in human and mouse cells and cell lines and in Drosophila melanogaster. J Nutr. 2008 Dec;138(12):2316-22. doi: 10.3945/jn.108.098673.
3 Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection. Sci Rep. 2016 Apr 26;6:25006. doi: 10.1038/srep25006.

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