Details of Epigenetic Molecule(EM)
| General Information of EM (ID: EM01167) | |||||||
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| Official Symbol |
EIF2B4
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| Official Full Name |
eukaryotic translation initiation factor 2B subunit delta
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| Synonym |
DKFZP586J0119;EIF-2B;EIF2B;EIF2Bdelta
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| Molecule Type |
Protein coding
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| Position On Chromosome |
chr2(Start:27364352 - End:27370486)
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| Strand |
-
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| Uniprot Entry | |||||||
| ENSG ID | |||||||
| Dnmivd Disease | |||||||
| Disease Relevance (Click to Show/Hide) | |||||||
| 2A00: Primary neoplasms of brain | Glioma [Primary neoplasms of brain] | ||||||
| Detailed Information |
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| 2A01: Primary neoplasms of meninges | Meningioma [Primary neoplasms of meninges] | ||||||
| Detailed Information |
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| 2B70: Malignant neoplasms of oesophagus | Barrett's esophagus and esophageal adenocarcinoma [Malignant neoplasms of oesophagus] | ||||||
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| 2B90: Malignant neoplasms of colon | Colorectal cancer [Malignant neoplasms of colon] | ||||||
| Detailed Information |
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| 2C30: Melanoma of skin | Cutaneous Melanoma [Melanoma of skin] | ||||||
| Detailed Information |
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| 2C60: Carcinoma of breast | Breast cancer [Carcinoma of breast] | ||||||
| Detailed Information |
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| 4A40: Lupus erythematosus | Systemic lupus erythematosus (SLE) [Lupus erythematosus] | ||||||
| Detailed Information |
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| 6A00: Disorders of intellectual development | Intellectual disability and congenital anomalies(ID/CA) [Disorders of intellectual development] | ||||||
| Detailed Information |
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| 6A02: Autism spectrum disorder | Autism [Autism spectrum disorder] | ||||||
| Detailed Information |
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| 6A20: Schizophrenia | Schizophrenia [Schizophrenia] | ||||||
| Detailed Information |
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| 6E8Z: Mental, behavioural or neurodevelopmental disorders | Psychiatric disorders [Mental, behavioural or neurodevelopmental disorders] | ||||||
| Detailed Information |
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| 8A01: Choreiform disorders | Huntington's disease (HD) [Choreiform disorders] | ||||||
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| 8A20: Alzheimer disease | Alzheimer's disease [Alzheimer disease] | ||||||
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| CA22: Chronic obstructive pulmonary disease | Chronic obstructive pulmonary disease (COPD) [Chronic obstructive pulmonary disease] | ||||||
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| CB03: Idiopathic interstitial pneumonitis | Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis] | ||||||
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| FA20: Rheumatoid arthritis | Rheumatoid arthritis [Rheumatoid arthritis] | ||||||
| Detailed Information |
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| GA10: Endometriosis | Endometriosis [Endometriosis] | ||||||
| Detailed Information |
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| JA24: Pre-eclampsia | Preeclampsia (PE) [Pre-eclampsia] | ||||||
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| XH1E13: Germinoma | Germinoma [Germinoma] | ||||||
| Detailed Information |
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| XH7F82: Glioblastoma | Glioblastoma [Glioblastoma] | ||||||
| Detailed Information |
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| XH8P29: Medulloblastoma | Medulloblastoma [Medulloblastoma] | ||||||
| Detailed Information |
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| XH8SH6: CNS embryonal tumour | Primitive neuroectodermal tumors [CNS embryonal tumour] | ||||||
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| XH9HQ1: Gastrointestinal stromal tumour | Gastrointestinal stromal tumors (GIST) [Gastrointestinal stromal tumour] | ||||||
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| Protein(s) with this epigenetic modification | |||||||
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| Protein Name: Rv2966c | |||||||
| Detailed Information |
Pro Info
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[1] | |||||
| Description |
Rv2966c could hypermethylate the non-CpG dinucleotides at the host EIF2B4 (TES) genetic loci during Mycobacterium tuberculosis H37Rv infection.
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| Protein Name: Rv2966c | |||||||
| Detailed Information |
Pro Info
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|
[1] | |||||
| Description |
Rv2966c could hypermethylate the non-CpG dinucleotides at the host EIF2B4 (geneBody) genetic loci during Mycobacterium tuberculosis H37Rv infection.
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| References | |||||
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| 1 | Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection. Sci Rep. 2016 Apr 26;6:25006. doi: 10.1038/srep25006. | ||||
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